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In 40.4% (93/230) of the specimens, stromal staining for SDC1 was observed. This proportion is slightly lower than that in a previous study by Lundin et al., in which stromal SDC1 immunoreactivity was noted in 58% of the specimens [5]. In the study conducted by Lundin et al., no statistically significant association between stromal SDC1 immunoreactivity and various clinicopathological parameters was identified [5]. However, in the present study, stromal SDC1 immunoreactivity was significantly associated with the male sex (p = 0.018) and marginally associated with distant metastasis (p = 0.072). To the best of our knowledge, there is no report of statistically significant association between stromal SDC1 expression and sex in various types of cancer. The reasons for the increase in stromal SDC1 expression in male patients with colorectal cancer are not readily evident. Further larger and more long-term studies should clarify this role. Meanwhile, it is unclear whether stromal SDC1 protein originates from ectodomain shedding from the tumor cell membrane or from within the stromal tissue itself [23]. The tumor microenvironment provides a compatible niche for the growth and progression of tumor cells, and stromal SDC1 may influence the tumor microenvironment by altering ECM-cytoskeleton linkage in the vicinity of the tumor [1]. It has recently been shown that the amount of stromal SDC1 protein can be increased by epithelial-mesenchymal interaction and is related to tumor progression and/or metastasis in several cancers [19, 24]. Ito et al. suggested that stromal SDC1 is secreted by cancer cells and entrapped by stroma cells, but when excessive SDC1 is produced from cancer cells, the remainder may still be deposited in cancer cells after shedding, which leads to some stimulation related to cancer progression [21].. Ninety five male Wistar rats were randomly assigned into four groups receiving the following treatments: myocardial ischemia with sympathetic nerve stimulation (MI-SNS, n = 25), sham-operation treated with sham stimulation (SO, n = 20), myocardial ischemia with sham stimulation (MI, n = 25), myocardial ischemia pretreated with sympathetic nerve stimulation (pSNS-MI, n = 25).. Twenty women and 53 men buy Clomiphene and arimidex for whom COPD was the leading cause of chronic HRF, and who were established on high-intensity NPPV, were identified from the database. Mean age was 64.2±9.6 years and mean body mass index (BMI) was 27.6±6.7 kg/m2. Mean cumulative smoking history was 41.9±28.5 pack-years. Pressure-limited NPPV was applied in 69 patients (Table 1), whereas four patients were established on volume-limited NPPV, due to better tolerance with a mean tidal volume of 683±197 ml and a mean breathing frequency of 21.3±3.8/min. Changes in physiological parameters after two months of NPPV are given in Table 2. After one year of NPPV, PaCO2 decreased from 51.7±6.6 to 44.9±12.7 (95%CI -11.6/-1.9; p=0.008) while PaO2 increased from 53.1±8.9 to 65.1±11.7 (95%CI 7.6/15.6; p<0.001). In 13 patients (18%), hematocrit was ≤39%; in 53 patients (73%), hematocrit ranged from 40 to 54%; and in seven patients (9%), hematocrit was ≥55%. Although hematocrit decreased significantly in the total group after two months of NPPV (Table 2), hematocrit increased from 36.2 (interquartile range 35.8/38.9) to 37.5 (interquartile range 36.0/39.5)% (p=0.016) in patients with an initial hematocrit ≤39%, but decreased from 55.8±0.9 to 48.2±5.7% (95%CI -13.6/-1.6; p=0.022) in patients with an initial hematocrit ≥55%, and from 46 (interquartile range 43.1/48.9) to 44.2 (interquartile range 42.1/46.3)% (p=0.008) in patients with an initial hematocrit ranging from 40 to 54%.. MICs of 250 and 500 µg/ml against the tested fungi. These MICs are. Twenty patients with moderate to severe COPD (age was [mean±standard deviation (SD)] 64±7 years buy Clomiphene and arimidex FEV1/FVC ratio was 45±11%) were randomized in a crossover, double-blind, placebo-controlled clinical trial to receive two puffs of either ipratropium bromide plus salbutamol (IB + S), IB + placebo (P), S + P, or P + P through metered dose inhalers (MDIs) daily over a 2-week period for each combination. At the end of each period, spirometry was obtained at baseline and 15, 30, 60, and 120 min after bronchodilator. Dyspnea was evaluated using a Borg scale during a 12-min walking test (12-MWT) performed at baseline and 120 min after MDIs use. In addition, the dyspnea component of the Chronic Respiratory Disease Questionnaire (CRDQ) and a diary of symptoms were used to evaluate this symptom.. imitated gestures per session, 0=no imitated movements; 1=63 imitated

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(Part Three)

The nightmares began a few weeks into my assignment. I had spent the first ten or twelve days immersed in the “story” I was about to tell with my photographs. As a photojournalist, my task was not merely to wander the village looking for striking images, though I did plenty of that, but to formulate a point of view. What story was I trying to tell? Was it “A Town Without Children”? Slowly I began to understand the story that needed to be told. It was about a village trying to return to normal after an unspeakable and unfathomable disastrous act of nature gone wild. And I was dealing with an angry village that shifted from weeping to shaking its fists. Sure nature went wild, but most believed that it needn’t have. There were early signs and the villagers felt betrayed. Somethings I could not capture with my cameras. There were places I could not enter to witness the incredible rage that boiled in the hearts of these rugged working class people.

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One night, in my cold garret bed, I awoke sweating. I was sick. I had come down with something. But I also was awakened by a dream – my little boy, only 5 months old and seemingly safe in Manhattan with Mary, his mom, was covered in mud that swirled around him and I couldn’t reach him to pull him out and he was consumed by the slurry. I thought it was a sign and wanted to call home but that in itself was a near impossible task. Not at four in the morning. Not from the Mackintosh.  The nightmare repeated itself even after I finally spoke to Mary on the phone and she assured me Benjamin was fine.

I looked forward to Jim Hick’s return from London. He’d come to pick up his interviews and we’d discuss the story. He’d bring me fresh film and take back to London my exposed film to be sent to the Life photo lab in New York.

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                                            Here I am with JIM HICKS on an Aberfan hillside

I depended on Jim for comfort and assurances and he told me that the editors were very pleased with what they were seeing. He also brought me contact sheets of the film that was already processed so I could see what I had shot. The story was beginning to take shape. Jim and I eventually were asked by the Mine Managers if we wanted to experience what it was like to be a mile down below ground.  They dressed us in coveralls, gave us helmets and headlamps, then took us down in the lift, way down. Far down. In the galleries below, the larger ‘rooms’ that had been cut and chiseled out of the rock, earth and coal seams, there was some light, but as we walked through the tunnels to where the miners were actually digging out the coal by hand, the only light we had were the beams of our headlamps.

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                                           Working Miner in the Merthyr Vale Coal Mines, Aberfan, Wales. Nov. 1961- © I C Rapoport

 

 

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       Up from the Pit -Selfie in the mirror. Jim Hicks standing behind me.

Much of my time was spend wandering the village looking to find photographs that would “speak” to the story at hand. On one such walk, along sidewalks on Nixonville. It was there a striking photograph presented itself. A woman, in her housedress, stood in in her doorway watching as the children were returning home from the nearby temporary school. I photograph her and luckily also captured her son plodding along, heading home. I spoke to her. Her name was Sheila Lewis and she lost a daughter in the disaster. She welcomed me inside to tell me her story.

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Sheila Lewis awaits her son Gwyn as he comes home from school. “I feel I must keep my eyes on him all the time, now. After the disaster…”
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Gwyn Lewis on the couch behind his mother, Sheila Lewis, as she reads from her daughter’s final school notes, papers she didn’t bring to school that fateful day

On one of Jim Hicks returns to Aberfan from London (he came several times and stayed a few nights) I tipped him off about a boy who had survived the disaster in his school room. He was the son of Llew Milk who had a small farm on the outskirts of Aberfan just north of the road to Merthyr Tydfil. The boy’s name was David Davies, perhaps the most common Welsh name after David Jones. Jim and I drove over to visit Ynysygored Farm and met with Llewellyn Davies and his family.

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                           Llewellyn Davies – father of David Davies, sole classroom survivor

Llew Davies (Llew pronounced like Slew without the ‘S’ – try it) told us how he had rushed from the farm to the school when he heard what had happened and was struck immediately by the frantic digging of miners, parents, firemen and others. He saw a row of muck-covered children’s bodies just as the emergency workers were draping them with bedsheets and covers supplied by nearby families. Llew joined the rescue attempt, stepping into the bucket brigade – a line of men and women passing empty pails to the diggers in the chaos and handing back out, pails filled with mud and rock. A primitive but necessary method considering that heavy earth moving equipment could not be utilized because the vibrations might cause more damage inside the school rooms and also because immediate silence was called for, time and again, as sounds of another child alive was heard beneath the dirt and brick. The small bodies were carried up and passed out on the same bucket brigade line with shouts of “Another coming up.” Llew took this one and carried it to the nearby Nurse who was attending to the line of bodies. When she poured water over the boy’s face, Llew realized he was holding the body of  his own son, David. The Nurse placed the 9 year down on the row, when she shouted: “This one’s alive!”

Yes, David was alive and they lifted him into an ambulance and drove immediately to Hospital.”It was a miracle,” Llewellyn told us. “Not one other child from David’s classroom survived. And no ones knows why.”

I found young David in his bedroom. He had been looking out his window and when he turned I took the first of many photographs of him.

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                                            First meeting with young David Davies in his room


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                                       David in the passageway between houses on his family farm

 

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Sitting under ‘The Big Tree’ where David used to play, now only several hundred yards from the disaster site. David still hadn’t comprehended the loss of all of his classmates.

 

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In the fields above his home, fields very much like those that the mud, dirt and stone tumbled down to smash into the primary school, David eyes the remaining Tips. Still a threat. Still something to fear.

David had no recollection of the event. To this day. David doesn’t recall much at all. At the time I photographed him, in the fields behind his home, he showed me the way he walked to school – along a dirt track that ran alongside a stream that was then filled with slurry and muck. Nearer to where the school once stood, the track had been obliterated by the avalanche.

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Just above the obliterated school site, a man delivers milk on what was the track that ran along the ridge.

I began making lists of photographs that were needed to complete the essay. The first child born in Aberfan after the disaster. The first wedding.  Simple signs of new life, or normality, islands in a turbulent ocean of grief and helplessness. I asked around and was told that a family not far from the Mack was expecting a child any day. I went to visit them to get permission to photograph the birth (I had already photographed my own child’s birth and filmed and photographed two other births of friends’ children). The mother-to-be was reluctant to have a stranger with a camera there in the room but agreed to let me be nearby and enter immediately afterwards. I asked where she would deliver and they took me to the front parlor, the room on the street. And I could not believe my eyes. Opposite the home was a perpendicular street  Any other home on the street would have had buildings across the way blocking the view beyond the village, but their house had this street and the opening provided us a view of the dreaded tips. She would have the baby on a cot, under the window, and outside we could see she was in the shadow of the tips.

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With the first child out of the way I now moved to find the first wedding and within a week, I heard there was a bride from Aberfan about to be married by the Reverend Hughes – a hero of the tragedy – the man who assumed command initially of the rescue operation when it was a chaotic mess of individuals digging and clawing to find the windows and doors into the muck covered school building. I sought out the family to gain permission to photograph the wedding.

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                                             The Reverend Hughes
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                            The Reverend Hughes

For weeks and weeks the children of the primary school, those who survived the horrendous events of the 21st of October, stayed home, close to their parents and neighbors.

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Girl who lost a sibling in the school, and who was saved from her front facing classroom, refused to leave her father’s side.

Eventually, a location in the Conservative Club was arranged for the Pantglas surviving children to attend some classes and try to return life to some semblance of normal comings and going.  I gathered the group of survivors and photographed them, having found the closing photograph to my photo essay on Aberfan: The Days After.

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