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Many scientists have successfully established their career at a young age by introducing novel techniques into their research areas and publishing in high-impact journals, while leaving the research fields with numerous artifacts and biased or erroneous conclusions. For example, there are ample spurious sequences deposited in various chimeric RNA databases on the internet, as we have pointed out previously [67, 68]. Although many of these artifacts, biases or errors have later been discovered and even corrected by others, those who made them and benefited from them with grants, publications and promotions have hardly been chastised, because the mistakes are made due to the innate flaws of the new techniques that “were formerly unaware of”. Actually, reviewing the publications involving the aforementioned new techniques in the past decades, smart young scientists have already found, probably unintentionally, a short cut to establish their career and renown, which is to introduce a new, sophisticated technique into their research areas without bothering to learn the associated flaws, simply because many readers, including grant and manuscript reviewers, likely lack the experience and knowledge of the technical details as well. There always is a latency between the time when a new and sophisticated technique is widely dispersed and the time when many technically derived problems are widely recognized. This latency period is used, intentionally or unintentionally, by many scientists for career development, although this “trick” has hardly been spelled out in the literature. Indeed, if we review those early publications in high-impact journals that involve some type of sophisticated technology, such as cDNA microarray that establishes the expression profiling realm, or the recent deep RNA sequencing that establishes the chimeric RNA, circular RNA, and other RNA-related bailiwicks, we will find that many peers get famous in these research provinces without being affected by the innate problems of the technique that are later well realized. Actually, in our opinion, a teeming number of spurious sequences are still being produced right now from the pipeline of “deep RNA sequencing” by many researchers who are using this technique and publishing data without knowing its detail and without commenting on the spuriousness. Readers, especially those as senior authors of many publications and the toasts of their research spheres, are encouraged to ask themselves, valiantly, how much technical detail they really know when they perform and publish those studies involving such as transcriptome or an “-omics” approach. Several technical-detail-related problems are listed below as examples to justify our points described above..

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