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We created a registry and prospectively analyzed data on a consecutive series of all patients who presented to our institution with symptomatic coronary artery disease between February 2005 and March 2007 and who were treated with the sirolimus- or the paclitaxel-eluting stent. The follow-up period after stent implantation was approximately 24 months. The primary end point was a major cardiac event, and the secondary end point was stent thrombosis. Informed consent was obtained from all subjects, and the study protocol was approved by the local ethical committee..
Hb Johnstown (beta109 (G11) Val->Leu) is a high oxygen affinity Hb variant and there are three reports in the literature. It was first reported by Jones and colleagues in Oregon, in 1990, in a healthy asymptomatic subject with mild erythrocytosis and left-shifted hemoglobin-O2 dissociation curve[10]. As with many other Hb variants, Hb Johnstown is silent on standard hemoglobin electrophoretic analyses, and was identified and isolated by reverse-phase HPLC of individual globin chains. Structural analysis revealed the substitution beta 109 (G11) Val ->Leu [10]. In 2000, the underlying beta globin mutation [beta-globin codon 109 (GTG ->CTG )] was first reported by Ropero and colleagues, in two unrelated families (total four subjects) of Basque extraction in Spain [11]. In one of these families, Hb Johnstown mutation was present in double heterozygosity with another beta 0 thalassemia mutation IVS-1-nt1 (G->A). In 2004, Feliu-Torres and colleagues reported Hb Johnstown [beta-globin codon 109 (GTG ->CTG )] in an eight year old girl, who had been referred for evaluation of erythrocytosis, in double heterozygosity with another beta globin mutation [IVS-I-1(G->A)]. Her asymptomatic mother was found to be heterozygous for Hb Johnstown mutation [12]. However, these reports described a causative G to C mutation that is different that mutation we describe in our subject with Hb Johnstown, namely G to T, both encoding the same amino acid; i.e. leucine and present in subjects not known to be of Spanish/Basque extraction.. for the design of ARIs, and in particular quinoxalinone is excellent for.